In 1994, I fell in love with Outkast. "Southernplayalisticadillacmuzik" still to this day gives me eargasms. In '96 "ATLiens" solidified them as my personal favorite musical act. They kept it rolling with "Aquemini". When "Stankonia" came out, I loved it, but "Ms. Jackson" got a little too mainstream popular and that was the first time I started to not like anything by Outkast - not because the song was bad, but because it got too popular. "So Fresh So Clean" also subsequently got too mainstream popular and my previously-unfailing love of Outkast started to fail. When Outkast dropped "Speakerboxxx/The Love Below", I immediately did not like "The Way You Move" and "Hey Ya!" primarily because they were instant mainstream pop hits.
Before Disturbed covered "Sound of Silence", they were one of my favorite hard rock acts. When I heard that song in a Burger King one day, I couldn't bring myself to listen to Disturbed anymore.
I tried listening to some newer Eminem stuff, but I just can't. His early stuff was trashing & mocking pop music and I dug it; but when he started doing legit pop hits himself I checked out.
If I'm listening to Metallica, I skip "Enter Sandman".
...I can't entirely explain why, but I cannot like mainstream popular music. It's disgusting to me.