When I brought up Ron Howard, I was more thinking about Opie, but Richie would qualify as well. He basically played Richie again in American Graffiti before he made the career shift.
Bussom Buddies was pretty iconic at the time. And Hanks was solidly locked into the dumb comedian mold until Philadelphia blew up his typecast shackles.
Bruce Willis and the Moonlighting/Die Hard dynamic is also a GREAT example. I remember the marketing shift for the movie when they removed Willis from the marketing material.
Another good one is Will Smith. ID4 completely shifted his image and made him a top flight leading man instead of just the rapper/comedy crossover tool.