If I were in a band with local gigs, I could see that being a great setup, with 8 presets and plenty of power to get over a drummer in a small/medium venue.
I went with the 50w, single 12 inch since I'm a bedroom player, but could use it in very small situations. Should I ever get good enough to gig, I'd likely go with your 100/212 or a different setup, where I'd be looking back to the tube amp cohort, similar to my old AC30 and a few pedals. I'm a little long in the tooth compared to my skill level for those thoughts, so my 50W will likely all I'll ever need......but wants are a different story.