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It's usually something like 16 hours for pork butt and 14 for brisket. I've never had a 22 pounder though.![]()
I smoked a full packer brisket that weighed over 22 lbs. on my offset smoker at 225 degrees once and it took 27 hours from start to finish.
Brisket is over-rated anyway. I don't like slow cooked beef...it's just not as good as pork is slow cooked. Not even close. ....and don't even mention the brisket farts!